Mangiferin (MG) is an active component in natural medicines, and various studies have been reported on pharmacological effects,\nbut the low solubility and bioavailability of MG limit its wide application. The aim of the present study was to investigate the\npharmacokinetic profiles of mangiferin (MG) and mangiferin monosodium salt (MG-Na) in rat plasma by UPLC-MS/MS, which\nwere then compared between the two groups. An appropriate high sensitivity and selectivity ultraperformance liquid chromatography-\ntandem mass spectrometry (UPLC-MS/MS) method was applied to the comparison of plasma pharmacokinetics in\nMG and MG-Na using carbamazepine as internal standard (IS)..........................
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